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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1975 1
1976 3
1977 1
1978 1
1979 1
1982 3
1983 1
1984 2
1985 4
1987 4
1988 3
1989 4
1990 1
1991 1
1992 3
1993 4
1994 5
1995 9
1996 4
1997 7
1998 3
1999 5
2000 10
2001 8
2002 17
2003 16
2004 17
2005 41
2006 42
2007 40
2008 51
2009 69
2010 73
2011 64
2012 85
2013 102
2014 112
2015 101
2016 103
2017 134
2018 133
2019 145
2020 162
2021 142
2022 108
2023 118
2024 48

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1,723 results

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Page 1
In-line sample trap columns with diatomite for large-volume injection in CZE-IM-MS.
Hooijschuur K, Liu X, Grootendorst A, Pieterman I, Sastre Toraño J. Hooijschuur K, et al. Electrophoresis. 2023 Feb;44(3-4):395-402. doi: 10.1002/elps.202200189. Epub 2022 Nov 16. Electrophoresis. 2023. PMID: 36333917 Free PMC article.
To provide smooth and complete filling of trap columns as well as to ensure higher and sustained flow rates though the columns, blends of cation and anion exchange particles with diatomite were used. The application of diatomite blends ensured the use of trap column …
To provide smooth and complete filling of trap columns as well as to ensure higher and sustained flow rates though the columns, blends …
Development of a Near Infrared Spectroscopy method for the in-line quantitative bilastine drug determination during pharmaceutical powders blending.
Biagi D, Nencioni P, Valleri M, Calamassi N, Mura P. Biagi D, et al. J Pharm Biomed Anal. 2021 Sep 10;204:114277. doi: 10.1016/j.jpba.2021.114277. Epub 2021 Jul 22. J Pharm Biomed Anal. 2021. PMID: 34332309
In particular, the use of NIR instrumentation should allow to control the bilastine concentration and the whole blending process, assuring the achievement of a homogeneous blend. ...Calibration and validation set were prepared according to a Placket-Burman experimen …
In particular, the use of NIR instrumentation should allow to control the bilastine concentration and the whole blending process, ass …
In-line Raman spectroscopic monitoring and feedback control of a continuous twin-screw pharmaceutical powder blending and tableting process.
Nagy B, Farkas A, Gyürkés M, Komaromy-Hiller S, Démuth B, Szabó B, Nusser D, Borbás E, Marosi G, Nagy ZK. Nagy B, et al. Int J Pharm. 2017 Sep 15;530(1-2):21-29. doi: 10.1016/j.ijpharm.2017.07.041. Epub 2017 Jul 16. Int J Pharm. 2017. PMID: 28723408
The integration of Process Analytical Technology (PAT) initiative into the continuous production of pharmaceuticals is indispensable for reliable production. The present paper reports the implementation of in-line Raman spectroscopy in a continuous blending and tabl …
The integration of Process Analytical Technology (PAT) initiative into the continuous production of pharmaceuticals is indispensable for rel …
In-line monitoring of a pharmaceutical blending process using FT-Raman spectroscopy.
Vergote GJ, De Beer TR, Vervaet C, Remon JP, Baeyens WR, Diericx N, Verpoort F. Vergote GJ, et al. Eur J Pharm Sci. 2004 Mar;21(4):479-85. doi: 10.1016/j.ejps.2003.11.005. Eur J Pharm Sci. 2004. PMID: 14998578
FT-Raman spectroscopy (in combination with a fibre optic probe) was evaluated as an in-line tool to monitor a blending process of diltiazem hydrochloride pellets and paraffinic wax beads. ...The results of this study proved that FT-Raman spectroscopy can be successf …
FT-Raman spectroscopy (in combination with a fibre optic probe) was evaluated as an in-line tool to monitor a blending process …
Determination and understanding of lead-lag between in-line NIR tablet press feed frame and off-line NIR tablet measurements.
Peeters M, Peeters E, Van Hauwermeiren D, Cogoni G, Liu Y, De Beer T. Peeters M, et al. Int J Pharm. 2022 Jan 5;611:121328. doi: 10.1016/j.ijpharm.2021.121328. Epub 2021 Nov 28. Int J Pharm. 2022. PMID: 34852290
Lead-lag is defined as the difference in time and API concentration between the measured in-line feed frame NIR response and the off-line NIR tablet data. Lead-lag results from the product formulation blend undergoing additional mixing after passing the NIR p …
Lead-lag is defined as the difference in time and API concentration between the measured in-line feed frame NIR response and the off- …
Raman spectroscopy as a process analytical technology (PAT) tool for the in-line monitoring and understanding of a powder blending process.
De Beer TR, Bodson C, Dejaegher B, Walczak B, Vercruysse P, Burggraeve A, Lemos A, Delattre L, Heyden YV, Remon JP, Vervaet C, Baeyens WR. De Beer TR, et al. J Pharm Biomed Anal. 2008 Nov 4;48(3):772-9. doi: 10.1016/j.jpba.2008.07.023. Epub 2008 Aug 7. J Pharm Biomed Anal. 2008. PMID: 18799281
The aim of this study is to propose a strategy to implement a PAT system in the blending step of pharmaceutical production processes. It was examined whether Raman spectroscopy can be used as PAT tool for the in-line and real-time endpoint monitoring and understandi …
The aim of this study is to propose a strategy to implement a PAT system in the blending step of pharmaceutical production processes. …
In-line quantification of two active ingredients in a batch blending process by near-infrared spectroscopy: influence of physical presentation of the sample.
Martínez L, Peinado A, Liesum L. Martínez L, et al. Int J Pharm. 2013 Jul 15;451(1-2):67-75. doi: 10.1016/j.ijpharm.2013.04.078. Epub 2013 May 4. Int J Pharm. 2013. PMID: 23651640
The aim of this study was to apply near-infrared (NIR) spectroscopy to the simultaneous in-line monitoring of two active pharmaceutical ingredients (APIs) in a pharmaceutical batch blending process. ...Furthermore, a PLS-2 model was also developed for the simultaneo …
The aim of this study was to apply near-infrared (NIR) spectroscopy to the simultaneous in-line monitoring of two active pharmaceutic …
Polycaprolactone Electrospun Fiber Mats Prepared Using Benign Solvents: Blending with Copper(II)-Chitosan Increases the Secretion of Vascular Endothelial Growth Factor in a Bone Marrow Stromal Cell Line.
Gritsch L, Liverani L, Lovell C, Boccaccini AR. Gritsch L, et al. Macromol Biosci. 2020 Mar;20(3):e1900355. doi: 10.1002/mabi.201900355. Epub 2020 Feb 5. Macromol Biosci. 2020. PMID: 32022997
Scaffold stability in phosphate buffered saline at 37 C is monitored over 1 week. A bone marrow stromal cell line (ST-2) is cultured for 7 days and its behavior is evaluated using SEM, fluorescence microscopy and a tetrazolium salt-based colorimetric assay. ...Most notably …
Scaffold stability in phosphate buffered saline at 37 C is monitored over 1 week. A bone marrow stromal cell line (ST-2) is cultured …
Evaluation of an in-line NIR spectroscopic method for the determination of the residence time in a tablet press.
De Leersnyder F, Vanhoorne V, Kumar A, Vervaet C, De Beer T. De Leersnyder F, et al. Int J Pharm. 2019 Jun 30;565:358-366. doi: 10.1016/j.ijpharm.2019.05.006. Epub 2019 May 7. Int J Pharm. 2019. PMID: 31075441
Turret speed had a major influence on the concentration profiles and RTD parameters. The in-line and off-line concentration profiles did not align with each other as spiking material was still detected in the tablets when no spiking material was observed in the powd …
Turret speed had a major influence on the concentration profiles and RTD parameters. The in-line and off-line concentration pr …
Effect of process parameters and formulation properties on the lead-lag between in-line NIR tablet press feed frame and off-line NIR tablet measurements.
Peeters M, Peeters E, Van Hauwermeiren D, Cogoni G, De Beer T. Peeters M, et al. Eur J Pharm Biopharm. 2023 Aug;189:251-263. doi: 10.1016/j.ejpb.2023.06.012. Epub 2023 Jun 23. Eur J Pharm Biopharm. 2023. PMID: 37356638
Lead-lag is defined as the difference in time and API concentration between the measured in-line NIR response inside the filling chamber of the feed frame and the off-line NIR tablet response. ...The in-line NIR measurements inside the filling chamber allow d …
Lead-lag is defined as the difference in time and API concentration between the measured in-line NIR response inside the filling cham …
1,723 results